Reaction Details  Report a problem with these data
Target
P2Y purinoceptor 6
Ligand
BDBM50341902
Substrate
n/a
Meas. Tech.
ChEMBL_743277 (CHEMBL1767476)
EC50
6100±n/a nM
Citation
 El-Tayeb, A; Qi, A; Nicholas, RA; Müller, CE Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J Med Chem 54:2878-90 (2011) [PubMed]  Article
Target
Name:
P2Y purinoceptor 6
Synonyms:
P2RY6 | P2RY6_HUMAN | P2Y purinoceptor 6 | P2Y6 | Pyrimidinergic receptor P2Y6
Type:
PROTEIN
Mol. Mass.:
36452.29
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1511151
Residue:
328
Sequence:
MEWDNGTGQALGLPPTTCVYRENFKQLLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRPHELLQKLTAKWQRQGR
  
Inhibitor
Name:
BDBM50341902
Synonyms:
5-Bromo-1-beta-D-ribofuranosyl(3H)pyrimidine-2,4-dione 5'-(gamma-phenylamino)triphosphate | CHEMBL1765120
Type:
Small organic molecule
Emp. Form.:
C15H19BrN3O14P3
Mol. Mass.:
638.148
SMILES:
O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(=O)Nc1ccccc1)n1cc(Br)c(=O)[nH]c1=O |r|
Structure:
Search PDB for entries with ligand similarity: