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Target
D(2) dopamine receptor
Ligand
BDBM50343295
Substrate
n/a
Meas. Tech.
ChEMBL_745700 (CHEMBL1776070)
EC50
951±n/a nM
Citation
 Zhang, L; Brodney, MA; Candler, J; Doran, AC; Duplantier, AJ; Efremov, IV; Evrard, E; Kraus, K; Ganong, AH; Haas, JA; Hanks, AN; Jenza, K; Lazzaro, JT; Maklad, N; McCarthy, SA; Qian, W; Rogers, BN; Rottas, MD; Schmidt, CJ; Siuciak, JA; Tingley, FD; Zhang, AQ 1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 positive allosteric modulators for the treatment of psychosis. J Med Chem 54:1724-39 (2011) [PubMed]  Article
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50343295
Synonyms:
2-((4-(2-Methoxy-phenyl)piperidin-1-yl)methyl)-1-methyl-1H-benzo[d]imidazole | CHEMBL1774101
Type:
Small organic molecule
Emp. Form.:
C21H25N3O
Mol. Mass.:
335.4427
SMILES:
COc1ccccc1C1CCN(Cc2nc3ccccc3n2C)CC1
Structure:
Search PDB for entries with ligand similarity: