Reaction Details  Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50343614
Substrate
n/a
Meas. Tech.
ChEMBL_746058 (CHEMBL1775445)
Ki
44±n/a nM
Citation
 Marrazzo, A; Cobos, EJ; Parenti, C; Aricò, G; Marrazzo, G; Ronsisvalle, S; Pasquinucci, L; Prezzavento, O; Colabufo, NA; Contino, M; González, LG; Scoto, GM; Ronsisvalle, G Novel potent and selectives ligands: evaluation of their agonist and antagonist properties. J Med Chem 54:3669-73 (2011) [PubMed]  Article
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50343614
Synonyms:
(+)-Methyl(1R,2S)-2-{[(3-endo)-3-(4-Chlorophenyl)-3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl]methyl}-1-phenylcyclopropanecarboxylate | CHEMBL1774579
Type:
Small organic molecule
Emp. Form.:
C25H28ClNO3
Mol. Mass.:
425.948
SMILES:
COC(=O)[C@@]1(C[C@@H]1CN1[C@@H]2CC[C@@H]1CC(O)(C2)c1ccc(Cl)cc1)c1ccccc1 |r,TLB:7:8:14.16.13:10.11,THB:15:14:8:10.11|
Structure:
Search PDB for entries with ligand similarity: