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Target
Sphingosine kinase 2
Ligand
BDBM50343835
Substrate
n/a
Meas. Tech.
ChEMBL_747638 (CHEMBL1777256)
Ki
4200±n/a nM
Citation
 Kennedy, AJ; Mathews, TP; Kharel, Y; Field, SD; Moyer, ML; East, JE; Houck, JD; Lynch, KR; Macdonald, TL Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells. J Med Chem 54:3524-48 (2011) [PubMed]  Article
Target
Name:
Sphingosine kinase 2
Synonyms:
SK 2 | SPHK2_MOUSE | SPK 2 | Sphingosine kinase 2 | Sphingosine kinase 2 (SPHK2) | Sphk2
Type:
Enzyme
Mol. Mass.:
65617.92
Organism:
Mus musculus (Mouse)
Description:
Q9JIA7
Residue:
617
Sequence:
MAPPPLLPVAASTPILHGEFGSYPANGPRFALTLTTQALHIQRLRPKPEARPRDGLVSLDEVSGCGTLQSRSPEDTAAYFCIYTYPRGRRGGRRRATRTFRADGATTYEENRAEAQRWATALTCLLRGVPLSGDQEITPELLPRKPRLLILVNPFGGRGLAWQRCMDHVVPMISEAGLSFNLIQTERQNHARELVQGLSLSEWEGIVTVSGDGLLYEVLNGLLDRPDWEDAVRMPIGVLPCGSGNALAGAVNHHGGFEQVVGVDLLLNCSLLLCRGGSHPLDLLSVTLASGSRCFSFLSVAWGFLSDVDIHSERFRALGSARFTLGAVLGLASLHTYRGRLSYLPATTEPALPIPGHSLPRAKSELVLAPAPAPAATHSPLHRSVSDLPLPLPQPALVSPGSPEPLPDLSLNGGGPELTGDWGGAGDAPLSPDPLLPSSPNALKTAQLSPIAEGPPEMPASSGFLPPTHSAPEASTWGPVDHLLPPLGSPLPQDWVTIEGEFVLMLGILPSHLCADLMAAPHARFDDGVVHLCWVRSGISRAALLRILLAMEHGNHFSLGCPHLGYAAARAFRLEPLTPRGLLTVDGELVEYGPIQAQVHPGLATLLTGPAGQKPQA
  
Inhibitor
Name:
BDBM50343835
Synonyms:
(S)-1-(4-(4-(3-(2-Cyclohexylethyl)phenyl)oxazol-2-yl)benzoyl)pyrrolidine-2-carboximidamide Hydrochloride | CHEMBL1774587
Type:
Small organic molecule
Emp. Form.:
C29H34N4O2
Mol. Mass.:
470.6059
SMILES:
NC(=N)[C@@H]1CCCN1C(=O)c1ccc(cc1)-c1nc(co1)-c1cccc(CCC2CCCCC2)c1 |r|
Structure:
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