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Target
Protein arginine N-methyltransferase 1 [11-371]
Ligand
BDBM50346716
Substrate
n/a
Meas. Tech.
ChEMBL_753235 (CHEMBL1799390)
IC50
10200±n/a nM
Citation
 Bissinger, EM; Heinke, R; Spannhoff, A; Eberlin, A; Metzger, E; Cura, V; Hassenboehler, P; Cavarelli, J; Schüle, R; Bedford, MT; Sippl, W; Jung, M Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg Med Chem 19:3717-31 (2011) [PubMed]  Article
Target
Name:
Protein arginine N-methyltransferase 1 [11-371]
Synonyms:
ANM1_HUMAN | HMT2 | HRMT1L2 | IR1B4 | PRMT1 | Protein arginine N-methyltransferase 1 (PRMT1) | Protein arginine methyltransferase 1 (PRMT1) | Protein-arginine N-methyltransferase 1
Type:
Protein
Mol. Mass.:
41506.52
Organism:
Homo sapiens (Human)
Description:
Q99873[11-371]
Residue:
361
Sequence:
MENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM50346716
Synonyms:
CHEMBL1797454
Type:
Small organic molecule
Emp. Form.:
C21H18Cl2N2O3S
Mol. Mass.:
449.35
SMILES:
Clc1ccc(cc1Cl)C(=O)Nc1ccc(cc1)S(=O)(=O)NCCc1ccccc1
Structure:
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