Reaction Details  Report a problem with these data
Target
Mitogen-activated protein kinase 10
Ligand
BDBM50352614
Substrate
n/a
Meas. Tech.
ChEMBL_767484 (CHEMBL1825596)
IC50
5±n/a nM
Citation
 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Tóth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration. Bioorg Med Chem Lett 21:5521-7 (2011) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 10
Synonyms:
JNK3 | JNK3A | MAP kinase p49 3F12 | MAPK10 | MK10_HUMAN | Mitogen-Activated Protein Kinase 10 (JNK3) | Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) | Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 | PRKM10 | SAPK1B | Stress-activated protein kinase JNK3 | c-Jun N-terminal kinase 3 (JNK3)
Type:
Enzyme
Mol. Mass.:
52586.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
464
Sequence:
MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
  
Inhibitor
Name:
BDBM50352614
Synonyms:
CHEMBL1822145
Type:
Small organic molecule
Emp. Form.:
C17H10BrF2N5O2S
Mol. Mass.:
466.259
SMILES:
Fc1cc2ccc(=O)n(CC(=O)Nc3scc(Br)c3-c3nnc[nH]3)c2cc1F
Structure:
Search PDB for entries with ligand similarity: