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Target
D(1A) dopamine receptor
Ligand
BDBM50353855
Substrate
n/a
Meas. Tech.
ChEMBL_769366 (CHEMBL1833372)
Ki
>10000±n/a nM
Citation
 Mésangeau, C; Amata, E; Alsharif, W; Seminerio, MJ; Robson, MJ; Matsumoto, RR; Poupaert, JH; McCurdy, CR Synthesis and pharmacological evaluation of indole-based sigma receptor ligands. Eur J Med Chem 46:5154-61 (2011) [PubMed]  Article
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM50353855
Synonyms:
CHEMBL1831166 | US9604926, Compound CM-361 | US9724435, Compound CM-361
Type:
Small organic molecule
Emp. Form.:
C29H31FN2O2
Mol. Mass.:
458.567
SMILES:
COc1cc2CCN(CCCCn3cc(-c4ccc(F)cc4)c4ccccc34)Cc2cc1OC
Structure:
Search PDB for entries with ligand similarity: