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Target
Hypoxia-inducible factor 1-alpha
Ligand
BDBM50354122
Substrate
n/a
Meas. Tech.
ChEMBL_770820 (CHEMBL1837625)
IC50
1200±n/a nM
Citation
 Huang, W; Huang, R; Attene-Ramos, MS; Sakamuru, S; Englund, EE; Inglese, J; Austin, CP; Xia, M Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1a inhibitors. Bioorg Med Chem Lett 21:5239-43 (2011) [PubMed]  Article
Target
Name:
Hypoxia-inducible factor 1-alpha
Synonyms:
BHLHE78 | HIF-1-alpha | HIF-1-alpha, HIF-2-alpha | HIF1A | HIF1A_HUMAN | Hypoxia inducible factors | Hypoxia-inducible factor 1 alpha | Hypoxia-inducible factor 1-alpha | MOP1 | PASD8 | von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A
Type:
Protein
Mol. Mass.:
92647.24
Organism:
Homo sapiens (Human)
Description:
Q16665
Residue:
826
Sequence:
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKRKMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
  
Inhibitor
Name:
BDBM50354122
Synonyms:
CHEMBL1836230
Type:
Small organic molecule
Emp. Form.:
C27H28N4O4
Mol. Mass.:
472.5356
SMILES:
CCOc1ccccc1-n1c(CN2CCN(CC2)C(=O)c2ccco2)nc2cccc(C)c2c1=O |(5.33,2.47,;4,1.7,;2.67,2.47,;2.67,4.01,;4,4.78,;4,6.32,;2.67,7.09,;1.33,6.32,;1.33,4.78,;,4.01,;,2.47,;1.33,1.7,;1.33,.16,;,-.61,;,-2.15,;1.33,-2.92,;2.67,-2.15,;2.67,-.61,;1.33,-4.46,;2.67,-5.23,;,-5.23,;-1.41,-4.61,;-2.44,-5.75,;-1.67,-7.09,;-.16,-6.77,;-1.33,1.7,;-2.67,2.47,;-4,1.7,;-5.33,2.47,;-5.33,4.01,;-4,4.78,;-4,6.32,;-2.67,4.01,;-1.33,4.78,;-1.33,6.32,)|
Structure:
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