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Target
Stromelysin-1
Ligand
BDBM50354624
Substrate
n/a
Meas. Tech.
ChEMBL_771372 (CHEMBL1839753)
Ki
23400±n/a nM
Citation
 Gooyit, M; Lee, M; Schroeder, VA; Ikejiri, M; Suckow, MA; Mobashery, S; Chang, M Selective water-soluble gelatinase inhibitor prodrugs. J Med Chem 54:6676-90 (2011) [PubMed]  Article
Target
Name:
Stromelysin-1
Synonyms:
MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1
Type:
Enzyme
Mol. Mass.:
53973.13
Organism:
Homo sapiens (Human)
Description:
P08254
Residue:
477
Sequence:
MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
  
Inhibitor
Name:
BDBM50354624
Synonyms:
CHEMBL1834422 | US10357546, ND-322 | US9951035, ND-322 (2)
Type:
Small organic molecule
Emp. Form.:
C15H15NO3S2
Mol. Mass.:
321.415
SMILES:
Nc1ccc(Oc2ccc(cc2)S(=O)(=O)CC2CS2)cc1
Structure:
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