Target
Carbonic anhydrase 14
Ligand
BDBM50358923
Substrate
n/a
Meas. Tech.
ChEMBL_790821 (CHEMBL1926274)
Ki
6.3±n/a nM
Citation
 Gitto, RDamiano, FMDe Luca, LFerro, SVullo, DSupuran, CTChimirri, A Synthesis and biological profile of new 1,2,3,4-tetrahydroisoquinolines as selective carbonic anhydrase inhibitors. Bioorg Med Chem 19:7003-7 (2011) [PubMed]  Article
Target
Name:
Carbonic anhydrase 14
Synonyms:
CA-XIV | CA14 | CAH14_HUMAN | Carbonate dehydratase XIV | Carbonic Anhydrase XIV | Carbonic anhydrase | Carbonic anhydrase 14 | Carbonic anhydrase 14 (CA XIV) | Carbonic anhydrase XIV (CA XIV)
Type:
Enzyme
Mol. Mass.:
37665.67
Organism:
Homo sapiens (Human)
Description:
Human (cloned) isozyme.
Residue:
337
Sequence:
MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVGCLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA
  
Inhibitor
Name:
BDBM50358923
Synonyms:
CHEMBL1923680
Type:
Small organic molecule
Emp. Form.:
C16H17N3O5S
Mol. Mass.:
363.388
SMILES:
COc1ccc2C(N(CCc2c1)S(N)(=O)=O)c1cccc(c1)[N+]([O-])=O
Structure:
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