Reaction Details  Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50276976
Substrate
n/a
Meas. Tech.
ChEMBL_799744 (CHEMBL1941450)
Ki
>1000±n/a nM
Citation
 Gitto, R; De Luca, L; Ferro, S; Buemi, MR; Russo, E; De Sarro, G; Costa, L; Ciranna, L; Prezzavento, O; Arena, E; Ronsisvalle, S; Bruno, G; Chimirri, A Synthesis and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors. J Med Chem 54:8702-6 (2011) [PubMed]  Article
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50276976
Synonyms:
2-(4-benzylpiperidin-1-yl)-1-(5-hydroxy-1Hindol-3-yl)ethanone | CHEMBL518480
Type:
Small organic molecule
Emp. Form.:
C22H24N2O2
Mol. Mass.:
348.4382
SMILES:
Oc1ccc2[nH]cc(C(=O)CN3CCC(Cc4ccccc4)CC3)c2c1
Structure:
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