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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50363303
Substrate
n/a
Meas. Tech.
ChEMBL_801009 (CHEMBL1948783)
IC50
1.1±n/a nM
Citation
 Herberich, B; Jackson, C; Wurz, RP; Pettus, LH; Sherman, L; Liu, Q; Henkle, B; Saris, CJ; Wong, LM; Chmait, S; Lee, MR; Mohr, C; Hsieh, F; Tasker, AS Identification of triazolopyridazinones as potent p38a inhibitors. Bioorg Med Chem Lett 22:1226-9 (2012) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50363303
Synonyms:
CHEMBL1945721
Type:
Small organic molecule
Emp. Form.:
C23H18ClF2N5O2
Mol. Mass.:
469.871
SMILES:
Cc1c(F)cc(cc1-c1cc2nnc(-c3c(F)cccc3Cl)n2n(C)c1=O)C(=O)NC1CC1 |(-5.99,4.05,;-4.45,4.05,;-3.68,5.37,;-4.44,6.71,;-2.13,5.36,;-1.37,4.02,;-2.15,2.7,;-3.69,2.71,;-4.47,1.39,;-6.02,1.4,;-6.8,.07,;-8.31,-.24,;-8.48,-1.77,;-7.08,-2.41,;-7.09,-3.95,;-5.76,-4.72,;-4.42,-3.95,;-5.76,-6.27,;-7.1,-7.03,;-8.43,-6.25,;-8.42,-4.71,;-9.75,-3.93,;-6.03,-1.28,;-4.49,-1.29,;-3.74,-2.63,;-3.71,.04,;-2.17,.03,;.17,4.01,;.95,5.33,;.93,2.67,;2.47,2.65,;3.79,1.86,;3.8,3.4,)|
Structure:
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