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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50363305
Substrate
n/a
Meas. Tech.
ChEMBL_801009 (CHEMBL1948783)
IC50
1±n/a nM
Citation
 Herberich, B; Jackson, C; Wurz, RP; Pettus, LH; Sherman, L; Liu, Q; Henkle, B; Saris, CJ; Wong, LM; Chmait, S; Lee, MR; Mohr, C; Hsieh, F; Tasker, AS Identification of triazolopyridazinones as potent p38a inhibitors. Bioorg Med Chem Lett 22:1226-9 (2012) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50363305
Synonyms:
CHEMBL1945722
Type:
Small organic molecule
Emp. Form.:
C24H21F2N5O2
Mol. Mass.:
449.4526
SMILES:
CCn1n2c(nnc2cc(-c2cc(ccc2C)C(=O)NC2CC2)c1=O)-c1c(F)cccc1F |(-1.54,-20.38,;-3.08,-20.36,;-3.84,-19.02,;-5.38,-19.01,;-6.43,-20.14,;-7.83,-19.5,;-7.65,-17.97,;-6.14,-17.66,;-5.37,-16.33,;-3.82,-16.35,;-3.03,-15.02,;-1.5,-15.04,;-.72,-13.71,;-1.48,-12.37,;-3.02,-12.36,;-3.8,-13.69,;-5.34,-13.68,;.82,-13.73,;1.6,-12.4,;1.58,-15.07,;3.12,-15.08,;4.44,-15.87,;4.46,-14.33,;-3.05,-17.69,;-1.51,-17.71,;-6.43,-21.68,;-7.77,-22.44,;-9.1,-21.66,;-7.78,-23.99,;-6.45,-24.77,;-5.11,-24,;-5.1,-22.45,;-3.77,-21.69,)|
Structure:
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