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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50363310
Substrate
n/a
Meas. Tech.
ChEMBL_801009 (CHEMBL1948783)
IC50
1±n/a nM
Citation
 Herberich, B; Jackson, C; Wurz, RP; Pettus, LH; Sherman, L; Liu, Q; Henkle, B; Saris, CJ; Wong, LM; Chmait, S; Lee, MR; Mohr, C; Hsieh, F; Tasker, AS Identification of triazolopyridazinones as potent p38a inhibitors. Bioorg Med Chem Lett 22:1226-9 (2012) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50363310
Synonyms:
CHEMBL1945839
Type:
Small organic molecule
Emp. Form.:
C25H23F2N5O2
Mol. Mass.:
463.4792
SMILES:
CCn1n2c(nnc2cc(-c2cc(cc(F)c2C)C(=O)NC2CC2)c1=O)-c1c(C)cccc1F |(19.08,-51,;17.54,-50.98,;16.78,-49.64,;15.24,-49.63,;14.19,-50.76,;12.79,-50.12,;12.97,-48.59,;14.48,-48.28,;15.25,-46.95,;16.8,-46.97,;17.58,-45.64,;19.12,-45.66,;19.9,-44.33,;19.14,-42.99,;17.6,-42.98,;16.83,-41.64,;16.82,-44.31,;15.28,-44.3,;21.44,-44.35,;22.22,-43.02,;22.2,-45.69,;23.74,-45.7,;25.06,-46.49,;25.07,-44.95,;17.57,-48.31,;19.11,-48.33,;14.19,-52.3,;12.85,-53.06,;11.52,-52.28,;12.84,-54.61,;14.17,-55.39,;15.51,-54.62,;15.52,-53.07,;16.85,-52.31,)|
Structure:
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