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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50363311
Substrate
n/a
Meas. Tech.
ChEMBL_801009 (CHEMBL1948783)
IC50
1.3±n/a nM
Citation
 Herberich, B; Jackson, C; Wurz, RP; Pettus, LH; Sherman, L; Liu, Q; Henkle, B; Saris, CJ; Wong, LM; Chmait, S; Lee, MR; Mohr, C; Hsieh, F; Tasker, AS Identification of triazolopyridazinones as potent p38a inhibitors. Bioorg Med Chem Lett 22:1226-9 (2012) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50363311
Synonyms:
CHEMBL1945715
Type:
Small organic molecule
Emp. Form.:
C23H19F2N5O2
Mol. Mass.:
435.4261
SMILES:
Cc1ccc(cc1-c1cc2nnc(-c3c(F)cccc3F)n2n(C)c1=O)C(=O)NC1CC1 |(-6.76,-13.46,;-5.22,-13.47,;-4.45,-12.14,;-2.9,-12.15,;-2.14,-13.49,;-2.92,-14.82,;-4.46,-14.8,;-5.24,-16.13,;-6.79,-16.11,;-7.57,-17.45,;-9.08,-17.75,;-9.25,-19.28,;-7.85,-19.92,;-7.86,-21.46,;-9.19,-22.22,;-10.52,-21.45,;-9.2,-23.77,;-7.87,-24.55,;-6.53,-23.79,;-6.53,-22.24,;-5.19,-21.47,;-6.8,-18.79,;-5.26,-18.8,;-4.51,-20.15,;-4.48,-17.47,;-2.94,-17.49,;-.6,-13.51,;.18,-12.18,;.16,-14.85,;1.7,-14.86,;3.02,-15.65,;3.03,-14.11,)|
Structure:
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