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Target
Nitric oxide synthase, endothelial
Ligand
BDBM50363624
Substrate
n/a
Meas. Tech.
ChEMBL_801785 (CHEMBL1947348)
Ki
37500±n/a nM
Citation
 Salerno, L; Modica, MN; Romeo, G; Pittalà, V; Siracusa, MA; Amato, ME; Acquaviva, R; Di Giacomo, C; Sorrenti, V Novel inhibitors of nitric oxide synthase with antioxidant properties. Eur J Med Chem 49:118-26 (2012) [PubMed]  Article
Target
Name:
Nitric oxide synthase, endothelial
Synonyms:
Ecnos | NOS3_MOUSE | Nitric-oxide synthase, endothelial | Nos3
Type:
PROTEIN
Mol. Mass.:
132922.33
Organism:
Mus musculus
Description:
ChEMBL_801785
Residue:
1202
Sequence:
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSQAPAPPSPTRPAPDHSPPLTRPPDGPRFPRVKNWEVGSITYDTLSAQAQQDGPCTSRRCLGSLVFPRKLQSRPTQGPSPTEQLLGQARDFINQYYNSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRTAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGDFRIWNSQLIRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPPELFTLPPEMVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSSEIGMRDLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWKGSAAKGAGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAARDIFSPKRSWKRQRYRLSTQAESLQLLPGLTHVHRRKMFQATILSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPPSTEPVAVEQLEKGSPGGPPPGWVRDPRLPPCTLRQALTYFLDITSPPSPRLLRLLSTLAEESSEQQELEALSQDPRRYEEWKWFSCPTLLEVLEQFPSVALPAPLILTQLPLLQPRYYSVSSAPSAHPGEIHLTIAVLAYRTQDGLGPLHYGVCSTWMSQLKAGDPVPCFIRGAPSFRLPPDPNLPCILVGPGTGIAPFRGFWQDRLHDIEIKGLQPAPMTLVFGCRCSQLDHLYRDEVLDAQQRGVFGQVLTAFSRDPGSPKTYVQDLLRTELAAEVHRVLCLEQGHMFVCGDVTMATSVLQTVQRILATEGGMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWSFDPPGPEIPGS
  
Inhibitor
Name:
BDBM50363624
Synonyms:
CHEMBL1946353
Type:
Small organic molecule
Emp. Form.:
C17H15N3O3
Mol. Mass.:
309.3193
SMILES:
Cc1cc2ncn(CC(=O)c3ccc(cc3)[N+]([O-])=O)c2cc1C
Structure:
Search PDB for entries with ligand similarity: