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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50281972
Substrate
n/a
Meas. Tech.
ChEBML_62807
IC50
1190±n/a nM
Citation
 Kozikowski, AP; Roberti, M; Johnson, KM; Bergmann, JS; Ball, RG SAR of cocaine: further exploration of structural variations at the C-2 center provides compounds of subnanomolar binding potency Bioorg Med Chem Lett 3:1327-1332 (1993)    Article
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3
Type:
Multi-pass membrane protein
Mol. Mass.:
68497.11
Organism:
Homo sapiens (Human)
Description:
Q01959
Residue:
620
Sequence:
MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHWLKV
  
Inhibitor
Name:
BDBM50281972
Synonyms:
1-[(2R,3S)-3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-yl]-2,2,2-trifluoro-ethanone | CHEMBL28376
Type:
Small organic molecule
Emp. Form.:
C16H17ClF3NO
Mol. Mass.:
331.76
SMILES:
CN1C2CCC1[C@@H]([C@H](C2)c1ccc(Cl)cc1)C(=O)C(F)(F)F |TLB:16:6:1:4.3,THB:0:1:6.7.8:4.3,9:7:1:4.3|
Structure:
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