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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50449824
Substrate
n/a
Meas. Tech.
ChEMBL_62807 (CHEMBL674120)
IC50
24±n/a nM
Citation
 Kozikowski, AP; Roberti, M; Johnson, KM; Bergmann, JS; Ball, RG SAR of cocaine: further exploration of structural variations at the C-2 center provides compounds of subnanomolar binding potency Bioorg Med Chem Lett 3:1327-1332 (1993)    Article
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3
Type:
Multi-pass membrane protein
Mol. Mass.:
68497.11
Organism:
Homo sapiens (Human)
Description:
Q01959
Residue:
620
Sequence:
MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHWLKV
  
Inhibitor
Name:
BDBM50449824
Synonyms:
CHEMBL2115570
Type:
Small organic molecule
Emp. Form.:
C16H19Cl2N
Mol. Mass.:
296.235
SMILES:
[H][C@@]1(CC2CCC([C@@H]1C=CCl)N2C)c1ccc(Cl)cc1 |TLB:13:1:11:5.4,THB:8:7:11:5.4,12:11:7.1.2:5.4|
Structure:
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