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Target
Type-2 angiotensin II receptor
Ligand
BDBM50282706
Substrate
n/a
Meas. Tech.
ChEMBL_35436 (CHEMBL643796)
IC50
1±n/a nM
Citation
 Glinka, TW; de Laszlo, SE; Tran, J; Chang, RS; Chen, T; Lotti, VJ; Greenlee, WJ L-161,638: A potent AT2selective quinazolinone angiotensin II binding inhibitor Bioorg Med Chem Lett 4:1479-1484 (1994)    Article
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41346.62
Organism:
RAT
Description:
Angiotensin II AT2 0 0::P35351
Residue:
363
Sequence:
MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
  
Inhibitor
Name:
BDBM50282706
Synonyms:
CHEMBL276853 | N-{2-Ethyl-4-oxo-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3,4-dihydro-quinazolin-6-yl}-N-(3-methyl-but-2-enyl)-benzamide
Type:
Small organic molecule
Emp. Form.:
C36H33N7O2
Mol. Mass.:
595.6929
SMILES:
CCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)N(CC=C(C)C)C(=O)c1ccccc1 |(2.49,-11.75,;2.48,-10.22,;1.14,-9.46,;-.19,-10.23,;-1.52,-9.47,;-2.86,-10.24,;-4.18,-9.47,;-4.18,-7.93,;-2.86,-7.16,;-1.52,-7.92,;-.2,-7.15,;-.21,-5.61,;1.14,-7.91,;2.47,-7.13,;3.8,-7.9,;5.13,-7.11,;6.46,-7.85,;6.48,-9.42,;5.15,-10.2,;3.81,-9.44,;7.81,-10.16,;7.82,-11.71,;9.16,-12.47,;10.49,-11.69,;10.47,-10.14,;9.14,-9.39,;9.12,-7.85,;10.35,-6.94,;9.86,-5.48,;8.33,-5.49,;7.85,-6.96,;-5.51,-7.16,;-5.53,-5.62,;-4.18,-4.85,;-4.18,-3.31,;-2.86,-2.54,;-5.53,-2.54,;-6.86,-7.93,;-6.86,-9.47,;-8.19,-7.16,;-9.52,-7.93,;-10.84,-7.17,;-10.84,-5.62,;-9.52,-4.85,;-8.19,-5.62,)|
Structure:
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