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Target
Excitatory amino acid transporter 3
Ligand
BDBM50093755
Substrate
n/a
Meas. Tech.
ChEMBL_68329 (CHEMBL680700)
IC50
6500±n/a nM
Citation
 Shimamoto, K; Shigeri, Y; Yasuda-Kamatani, Y; Lebrun, B; Yumoto, N; Nakajima, T Syntheses of optically pure beta-hydroxyaspartate derivatives as glutamate transporter blockers. Bioorg Med Chem Lett 10:2407-10 (2001) [PubMed]
Target
Name:
Excitatory amino acid transporter 3
Synonyms:
EAA3_HUMAN | EAAC1 | EAAT3 | Excitatory Amino Acid EAAT3 | HEAAC1 | SLC1A1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57096.71
Organism:
Homo sapiens (Human)
Description:
Excitatory Amino Acid EAAT3 0 HUMAN::P43005
Residue:
524
Sequence:
MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMTEESFTAVMTTAISKNKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVNIVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF
  
Inhibitor
Name:
BDBM50093755
Synonyms:
(2S, 3S)-3-Amino-2-(naphthalen-2-ylmethoxy)-pentanedioic acid | CHEMBL78795
Type:
Small organic molecule
Emp. Form.:
C15H15NO5
Mol. Mass.:
289.2833
SMILES:
N[C@@H]([C@H](OCc1ccc2ccccc2c1)C(O)=O)C(O)=O
Structure:
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