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Target
Cyclin-dependent kinase 4
Ligand
BDBM50086652
Substrate
n/a
Meas. Tech.
ChEBML_51149
IC50
5600±n/a nM
Citation
 Ryu, CK; Kang, HY; Lee, SK; Nam, KA; Hong, CY; Ko, WG; Lee, BH 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents. Bioorg Med Chem Lett 10:461-4 (2000) [PubMed]
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM50086652
Synonyms:
5-(4-Methoxy-phenylamino)-2-methyl-benzothiazole-4,7-dione | CHEMBL143570
Type:
Small organic molecule
Emp. Form.:
C15H12N2O3S
Mol. Mass.:
300.332
SMILES:
COc1ccc(NC2=CC(=O)c3sc(C)nc3C2=O)cc1 |t:7|
Structure:
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