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Target
Phospho-N-acetylmuramoyl-pentapeptide-transferase
Ligand
BDBM50102054
Substrate
n/a
Meas. Tech.
ChEBML_66299
IC50
>900000±n/a nM
Citation
 Thorarensen, A; Presley-Bodnar, AL; Marotti, KR; Boyle, TP; Heckaman, CL; Bohanon, MJ; Tomich, PK; Zurenko, GE; Sweeney, MT; Yagi, BH 3-Arylpiperidines as potentiators of existing antibacterial agents. Bioorg Med Chem Lett 11:1903-6 (2001) [PubMed]
Target
Name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
Synonyms:
MRAY_ECOLI | Phospho-N-acetylmuramoyl-pentapeptide-transferase/UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase | mraY | murX
Type:
PROTEIN
Mol. Mass.:
39889.38
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_1454117
Residue:
360
Sequence:
MLVWLAEHLVKYYSGFNVFSYLTFRAIVSLLTALFISLWMGPRMIAHLQKLSFGQVVRNDGPESHFSKRGTPTMGGIMILTAIVISVLLWAYPSNPYVWCVLVVLVGYGVIGFVDDYRKVVRKDTKGLIARWKYFWMSVIALGVAFALYLAGKDTPATQLVVPFFKDVMPQLGLFYILLAYFVIVGTGNAVNLTDGLDGLAIMPTVFVAGGFALVAWATGNMNFASYLHIPYLRHAGELVIVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGIIAVLLRQEFLLVIMGGVFVVETLSVILQVGSFKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISLMLVLIGLATLKVR
  
Inhibitor
Name:
BDBM50102054
Synonyms:
3-[2-(2,5-Dimethyl-phenyl)-ethyl]-piperidine | CHEMBL56915
Type:
Small organic molecule
Emp. Form.:
C15H23N
Mol. Mass.:
217.3498
SMILES:
Cc1ccc(C)c(CCC2CCCNC2)c1
Structure:
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