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Target
Thermolysin
Ligand
BDBM50121452
Substrate
n/a
Meas. Tech.
ChEBML_210401
Ki
11±n/a nM
Citation
 Kim, J; Glekas, A; McN Sieburth, S Silanediol-based inhibitor of thermolysin. Bioorg Med Chem Lett 12:3625-7 (2002) [PubMed]
Target
Name:
Thermolysin
Synonyms:
THER_BACTH | npr
Type:
PROTEIN
Mol. Mass.:
60097.54
Organism:
Bacillus thermoproteolyticus
Description:
ChEMBL_1468794
Residue:
548
Sequence:
MKMKMKLASFGLAAGLAAQVFLPYNALASTEHVTWNQQFQTPQFISGDLLKVNGTSPEELVYQYVEKNENKFKFHENAKDTLQLKEKKNDNLGFTFMRFQQTYKGIPVFGAVVTSHVKDGTLTALSGTLIPNLDTKGSLKSGKKLSEKQARDIAEKDLVANVTKEVPEYEQGKDTEFVVYVNGDEASLAYVVNLNFLTPEPGNWLYIIDAVDGKILNKFNQLDAAKPGDVKSITGTSTVGVGRGVLGDQKNINTTYSTYYYLQDNTRGNGIFTYDAKYRTTLPGSLWADADNQFFASYDAPAVDAHYYAGVTYDYYKNVHNRLSYDGNNAAIRSSVHYSQGYNNAFWNGSQMVYGDGDGQTFIPLSGGIDVVAHELTHAVTDYTAGLIYQNESGAINEAISDIFGTLVEFYANKNPDWEIGEDVYTPGISGDSLRSMSDPAKYGDPDHYSKRYTGTQDNGGVHINSGIINKAAYLISQGGTHYGVSVVGIGRDKLGKIFYRALTQYLTPTSNFSQLRAAAVQSATDLYGSTSQEVASVKQAFDAVGVK
  
Inhibitor
Name:
BDBM50121452
Synonyms:
(S)-2-{(S)-2-[(Benzyloxycarbonylamino-methyl)-hydroxy-phosphonium-methyl]-4-methyl-pentanoylamino}-4-methyl-pentanoic acid anion
Type:
Small organic molecule
Emp. Form.:
C22H33N2O7P
Mol. Mass.:
468.4815
SMILES:
CC(C)C[C@H](CP(O)([O-])=CNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(C)C)C([O-])=O
Structure:
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