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Target
Carbonic anhydrase 4
Ligand
BDBM50135606
Substrate
n/a
Meas. Tech.
ChEBML_45429
Ki
8±n/a nM
Citation
 Casini, A; Scozzafava, A; Mincione, F; Menabuoni, L; Starnotti, M; Supuran, CT Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide. Bioorg Med Chem Lett 13:2867-73 (2003) [PubMed]
Target
Name:
Carbonic anhydrase 4
Synonyms:
CA-IV | CA4 | CAH4_BOVIN | Carbonate dehydratase IV | Carbonic Anhydrase IV | Carbonic anhydrase | Carbonic anhydrase 4
Type:
Enzyme
Mol. Mass.:
35152.74
Organism:
Bos taurus (bovine)
Description:
Bovine isozyme, isolated from lung microsomes
Residue:
312
Sequence:
MRLLLALLVLAAAPPQARAASHWCYQIQVKPSNYTCLEPDEWEGSCQNNRQSPVNIVTAKTQLDPNLGRFSFSGYNMKHQWVVQNNGHTVMVLLENKPSIAGGGLSTRYQATQLHLHWSRAMDRGSEHSFDGERFAMEMHIVHEKEKGLSGNASQNQFAEDEIAVLAFMVEDGSKNVNFQPLVEALSDIPRPNMNTTMKEGVSLFDLLPEEESLRHYFRYLGSLTTPTCDEKVVWTVFQKPIQLHRDQILAFSQKLFYDDQQKVNMTDNVRPVQSLGQRQVFRSGAPGLLLAQPLPTLLAPVLACLTVGFLR
  
Inhibitor
Name:
BDBM50135606
Synonyms:
CHEMBL99337 | N-(2-Diethylamino-ethyl)-4-[3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidenesulfamoyl]-benzamide
Type:
Small organic molecule
Emp. Form.:
C16H24N6O5S3
Mol. Mass.:
476.594
SMILES:
CCN(CC)CCNC(=O)c1ccc(cc1)S(=O)(=O)\N=c1\sc(nn1C)S(N)(=O)=O
Structure:
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