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Target
Dihydrofolate reductase
Ligand
BDBM50022280
Substrate
n/a
Meas. Tech.
ChEBML_54902
IC50
>100000±n/a nM
Citation
 Ghazala, M; Nair, MG; Toghiyani, TR; Kisliuk, RL; Gaumont, Y; Kalman, TI Folate analogues. 25. Synthesis and biological evaluation of N10-propargylfolic acid and its reduced derivatives. J Med Chem 29:1263-9 (1987) [PubMed]
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_LACCA | dhfR | folA
Type:
PROTEIN
Mol. Mass.:
18437.08
Organism:
Lactobacillus casei
Description:
ChEMBL_1357878
Residue:
163
Sequence:
MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTNVVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLAGSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
  
Inhibitor
Name:
BDBM50022280
Synonyms:
4-[(2-Amino-4-hydroxy-pteridin-6-ylmethyl)-prop-2-ynyl-amino]-benzoic acid | CHEMBL279732
Type:
Small organic molecule
Emp. Form.:
C17H14N6O3
Mol. Mass.:
350.3315
SMILES:
Nc1nc2ncc(CN(CC#C)c3ccc(cc3)C(O)=O)nc2c(=O)[nH]1
Structure:
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