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Target
Purine nucleoside phosphorylase
Ligand
BDBM50022242
Substrate
n/a
Meas. Tech.
ChEBML_162174
IC50
142500±n/a nM
Citation
 Sircar, JC; Suto, MJ; Scott, ME; Dong, MK; Gilbertsen, RB Inhibitors of human purine nucleoside phosphorylase. Synthesis, purine nucleoside phosphorylase inhibition, and T-cell cytotoxicity of 2,5-diaminothiazolo[5,4-d]pyrimidin-7(6H)-one and 2,5-diaminothiazolo[4,5-d]pyrimidin-7(6H)-one. Two thio isosteres of 8-aminoguanine. J Med Chem 29:1804-6 (1986) [PubMed]
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50022242
Synonyms:
2,5-Diamino-6H-thiazolo[5,4-d]pyrimidin-7-one | CHEMBL50940
Type:
Small organic molecule
Emp. Form.:
C5H5N5OS
Mol. Mass.:
183.191
SMILES:
Nc1nc2c(nc(N)[nH]c2=O)s1
Structure:
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