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Target
Purine nucleoside phosphorylase
Ligand
BDBM50022243
Substrate
n/a
Meas. Tech.
ChEBML_162174
IC50
1550±n/a nM
Citation
 Sircar, JC; Suto, MJ; Scott, ME; Dong, MK; Gilbertsen, RB Inhibitors of human purine nucleoside phosphorylase. Synthesis, purine nucleoside phosphorylase inhibition, and T-cell cytotoxicity of 2,5-diaminothiazolo[5,4-d]pyrimidin-7(6H)-one and 2,5-diaminothiazolo[4,5-d]pyrimidin-7(6H)-one. Two thio isosteres of 8-aminoguanine. J Med Chem 29:1804-6 (1986) [PubMed]
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50022243
Synonyms:
2,8-Diamino-1,9-dihydro-purin-6-one | 8-AMINOGUANINE | CHEMBL8040
Type:
Small organic molecule
Emp. Form.:
C5H6N6O
Mol. Mass.:
166.1407
SMILES:
Nc1nc2nc(N)[nH]c(=O)c2[nH]1
Structure:
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