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Target
Aromatase
Ligand
BDBM50014320
Substrate
n/a
Meas. Tech.
ChEBML_51211
Ki
24±n/a nM
Citation
 Cole, PA; Robinson, CH Mechanism and inhibition of cytochrome P-450 aromatase. J Med Chem 33:2933-42 (1990) [PubMed]
Target
Name:
Aromatase
Synonyms:
Arom | Aromatase | CP19A_RAT | CYPXIX | Cyp19 | Cyp19a1 | Cytochrome P450 19A1 | Estrogen synthetase | P-450AROM
Type:
PROTEIN
Mol. Mass.:
58418.09
Organism:
Rattus norvegicus
Description:
ChEMBL_51211
Residue:
508
Sequence:
MFLEMLNPMHYNVTIMVPETVPVSAMPLLLIMGLLLLIRNCESSSSIPGPGYCLGIGPLISHGRFLWMGIGSACNYYNKMYGEFMRVWISGEETLIISKSSSMVHVMKHSNYISRFGSKRGLQCIGMHENGIIFNNNPSLWRTVRPFFMKALTGPGLIRMVEVCVESIKQHLDRLGDVTDNSGYVDVVTLMRHIMLDTSNTLFLGIPLDESSIVKKIQGYFNAWQALLIKPNIFFKISWLYRKYERSVKDLKDEIEILVEKKRQKVSSAEKLEDCMDFATDLIFAERRGDLTKENVNQCILEMLIAAPDTMSVTLYVMLLLIAEYPEVETAILKEIHTVVGDRDIRIGDVQNLKVVENFINESLRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNIGRMHRLEYFPKPNEFTLENFEKNVPYRYFQPFGFGPRSCAGKYIAMVMMKVVLVTLLKRFHVKTLQKRCIENMPKNNDLSLHLDEDSPIVEIIFRHIFNTPFLQCLYISL
  
Inhibitor
Name:
BDBM50014320
Synonyms:
8-Chloro-5-(4-chloro-phenyl)-5H-indeno[1,2-d]pyrimidine(LY 113174) | CHEMBL101324 | LY-113174
Type:
Small organic molecule
Emp. Form.:
C17H10Cl2N2
Mol. Mass.:
313.181
SMILES:
Clc1ccc(cc1)C1c2ccc(Cl)cc2-c2ncncc12
Structure:
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