Reaction Details  Report a problem with these data
Target
Adenosylhomocysteinase
Ligand
BDBM50011352
Substrate
n/a
Meas. Tech.
ChEMBL_196879 (CHEMBL807531)
Ki
150000±n/a nM
Citation
 Jarvi, ET; McCarthy, JR; Mehdi, S; Matthews, DP; Edwards, ML; Prakash, NJ; Bowlin, TL; Sunkara, PS; Bey, P 4',5'-unsaturated 5'-halogenated nucleosides. Mechanism-based and competitive inhibitors of S-adenosyl-L-homocysteine hydrolase. J Med Chem 34:647-56 (1991) [PubMed]
Target
Name:
Adenosylhomocysteinase
Synonyms:
Adenosylhomocysteinase | Ahcy | SAHH_RAT
Type:
PROTEIN
Mol. Mass.:
47537.52
Organism:
Rattus norvegicus
Description:
ChEMBL_1507790
Residue:
432
Sequence:
MADKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY
  
Inhibitor
Name:
BDBM50011352
Synonyms:
5-(6-Amino-purin-9-yl)-2-fluoromethylene-tetrahydro-furan-3-ol | CHEMBL3349335
Type:
Small organic molecule
Emp. Form.:
C10H10FN5O2
Mol. Mass.:
251.2171
SMILES:
Nc1ncnc2n(cnc12)[C@H]1C[C@H](O)\C(O1)=C\F
Structure:
Search PDB for entries with ligand similarity: