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Target
Purine nucleoside phosphorylase
Ligand
BDBM50005794
Substrate
n/a
Meas. Tech.
ChEBML_162178
IC50
112000±n/a nM
Citation
 Woo, PW; Kostlan, CR; Sircar, JC; Dong, MK; Gilbertsen, RB Inhibitors of human purine nucleoside phosphorylase. Synthesis and biological activities of 8-amino-3-benzylhypoxanthine and related analogues. J Med Chem 35:1451-7 (1992) [PubMed]
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50005794
Synonyms:
3-Benzyl-1,9-dihydro-purin-6-one | 3-Benzyl-3,7-dihydro-purin-6-one | CHEMBL415041
Type:
Small organic molecule
Emp. Form.:
C12H10N4O
Mol. Mass.:
226.234
SMILES:
Oc1ncn(Cc2ccccc2)c2ncnc12
Structure:
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