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Target
B2 bradykinin receptor
Ligand
BDBM50045223
Substrate
n/a
Meas. Tech.
ChEBML_40423
Ki
25000±n/a nM
Citation
 Salvino, JM; Seoane, PR; Douty, BD; Awad, MM; Dolle, RE; Houck, WT; Faunce, DM; Sawutz, DG Design of potent non-peptide competitive antagonists of the human bradykinin B2 receptor. J Med Chem 36:2583-4 (1993) [PubMed]
Target
Name:
B2 bradykinin receptor
Synonyms:
B2 BRADYKININ | B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKR2 | BKRB2_HUMAN | Bradykinin B2 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44467.17
Organism:
Homo sapiens (Human)
Description:
B2 BRADYKININ BDKRB2 HUMAN::P30411
Residue:
391
Sequence:
MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ
  
Inhibitor
Name:
BDBM50045223
Synonyms:
tributyl{4-[({[(E)-(cyclohexylamino)(cyclohexyliminio)1-(phenylmethyl)methyl]amino}acetyl)amino]benzyl}phosphonium; Chloride; hydrochloride
Type:
Small organic molecule
Emp. Form.:
C35H59N4OP
Mol. Mass.:
582.8418
SMILES:
CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccccc2)N\C(NC(C)C)=[NH+]\C(C)C)cc1
Structure:
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