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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Ligand
BDBM50044880
Substrate
n/a
Meas. Tech.
ChEMBL_213114 (CHEMBL873905)
IC50
600±n/a nM
Citation
 Jones, CD; Audia, JE; Lawhorn, DE; McQuaid, LA; Neubauer, BL; Pike, AJ; Pennington, PA; Stamm, NB; Toomey, RE; Hirsch, KS Nonsteroidal inhibitors of human type I steroid 5-alpha-reductase. J Med Chem 36:421-3 (1993) [PubMed]
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:
Enzyme
Mol. Mass.:
29472.80
Organism:
Homo sapiens (Human)
Description:
P18405
Residue:
259
Sequence:
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
  
Inhibitor
Name:
BDBM50044880
Synonyms:
8-Fluoro-1,4,5,6-tetrahydro-2H-benzo[f]quinolin-3-one | CHEMBL134114
Type:
Small organic molecule
Emp. Form.:
C13H12FNO
Mol. Mass.:
217.2389
SMILES:
Fc1ccc2C3=C(CCc2c1)NC(=O)CC3 |c:5|
Structure:
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