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Target
Prolyl endopeptidase
Ligand
BDBM50038896
Substrate
n/a
Meas. Tech.
ChEMBL_157472 (CHEMBL765791)
IC50
18±n/a nM
Citation
 Tanaka, Y; Niwa, S; Nishioka, H; Yamanaka, T; Torizuka, M; Yoshinaga, K; Kobayashi, N; Ikeda, Y; Arai, H New potent prolyl endopeptidase inhibitors: synthesis and structure-activity relationships of indan and tetralin derivatives and their analogues. J Med Chem 37:2071-8 (1994) [PubMed]
Target
Name:
Prolyl endopeptidase
Synonyms:
PE | PEP | POP | PPCE_HUMAN | PREP | Post-proline cleaving enzyme | Prolyl oligopeptidase
Type:
Enzyme
Mol. Mass.:
80688.50
Organism:
Homo sapiens (Human)
Description:
P48147
Residue:
710
Sequence:
MLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILSDDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTHDGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRQSPNYRVINIDFRDPEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNILQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYGCSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIVGRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNVDWIP
  
Inhibitor
Name:
BDBM50038896
Synonyms:
1-[(R)-4-(Pyrrolidine-1-carbonyl)-thiazolidin-3-yl]-2-(4,5,6,7-tetrahydro-benzo[b]thiophen-5-yl)-ethanone | CHEMBL304020
Type:
Small organic molecule
Emp. Form.:
C18H24N2O2S2
Mol. Mass.:
364.525
SMILES:
O=C(CC1CCc2sccc2C1)N1CSC[C@H]1C(=O)N1CCCC1
Structure:
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