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Target
Nitric oxide synthase, inducible
Ligand
BDBM50072297
Substrate
n/a
Meas. Tech.
ChEMBL_89371 (CHEMBL699604)
IC50
2200±n/a nM
Citation
 Moore, WM; Webber, RK; Jerome, GM; Tjoeng, FS; Misko, TP; Currie, MG L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. J Med Chem 37:3886-8 (1994) [PubMed]
Target
Name:
Nitric oxide synthase, inducible
Synonyms:
NOS2_RAT | Nos2
Type:
PROTEIN
Mol. Mass.:
130642.55
Organism:
Rattus norvegicus
Description:
ChEMBL_976228
Residue:
1147
Sequence:
MACPWKFLFRVKSYQGDLKEEKDINNNVEKTPGAIPSPTTQDDPKSHKHQNGFPQFLTGTAQNVPESLDKLHVTPSTRPQHVRIKNWGNGEIFHDTLHHKATSDISCKSKLCMGSIMNSKSLTRGPRDKPTPVEELLPQAIEFINQYYGSFKEAKIEEHLARLEAVTKEIETTGTYQLTLDELIFATKMAWRNAPRCIGRIQWSNLQVFDARSCSTASEMFQHICRHILYATNSGNIRSAITVFPQRSDGKHDFRIWNSQLIRYAGYQMPDGTIRGDPATLEFTQLCIDLGWKPRYGRFDVLPLVLQAHGQDPEVFEIPPDLVLEVTMEHPKYEWFQELGLKWYALPAVANMLLEVGGLEFPACPFNGWYMGTEIGVRDFCDTQRYNILEEVGRRMGLETHTLASLWKDRAVTEINAAVLHSFQKQNVTIMDHHTASESFMKHMQNEYRARGGCPADWIWLVPPVSGSITPVFHQEMLNYVLSPFYYYQIEPWKTHIWQDEKLRPRRREIRFTVLVKAVFFASVLMRKVMASRVRATVLFATETGKSEALARDLAALFSYAFNTKVVCMEQYKANTLEEEQLLLVVTSTFGNGDCPSNGQTLKKSLFMMKELGHTFRYAVFGLGSSMYPQFCAFAHDIDQKLSHLGASQLAPTGEGDELSGQEDAFRSWAVQTFRAACETFDVRSKHCIQIPKRYTSNATWEPEQYKLTQSPESLDLNKALSSIHAKNVFTMRLKSLQNLQSEKSSRTTLLVQLTFEGSRGPSYLPGEHLGIFPGNQTALVQGILERVVDCSSPDQTVCLEVLDESGSYWVKDKRLPPCSLRQALTYFLDITTPPTQLQLHKLARFATEETHRQRLEALCQPSEYNDWKFSNNPTFLEVLEEFPSLRVPAAFLLSQLPILKPRYYSISSSQDHTPSEVHLTVAVVTYRTRDGQGPLHHGVCSTWINNLKPEDPVPCFVRSVSGFQLPEDPSQPCILIGPGTGIAPFRSFWQQRLHDSQHRGLKGGRMTLVFGCRHPEEDHLYQEEMQEMVRKGVLFQVHTGYSRLPGKPKVYVQDILQKELADEVFSVLHGEQGHLYVCGDVRMARDVATTLKKLVAAKLNLSEEQVEDYFFQLKSQKRYHEDIFGAVFSYGAKKGNTLEEPKGTRL
  
Inhibitor
Name:
BDBM50072297
Synonyms:
(S)-5-Acetimidoylamino-2-amino-pent | (S)-5-Acetimidoylamino-2-amino-pentanoic acid | 5-Acetimidoylamino-2-(S)-amino-pentanoic acid | CHEMBL11471 | L-NIO, 12 | N5-(1-iminoethyl)-L-ornithine | N5-IMINOETHYL-L-ORNITHINE
Type:
Small organic molecule
Emp. Form.:
C7H15N3O2
Mol. Mass.:
173.2129
SMILES:
CC(N)=NCCC[C@H](N)C(O)=O |r,w:3.3|
Structure:
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