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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Ligand
BDBM50369335
Substrate
n/a
Meas. Tech.
ChEMBL_202897 (CHEMBL807649)
IC50
7.3±n/a nM
Citation
 Guarna, A; Belle, C; Machetti, F; Occhiato, EG; Payne, AH; Cassiani, C; Comerci, A; Danza, G; De Bellis, A; Dini, S; Marrucci, A; Serio, M 19-nor-10-azasteroids: a novel class of inhibitors for human steroid 5alpha-reductases 1 and 2. J Med Chem 40:1112-29 (1997) [PubMed]  Article
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Type:
Enzyme
Mol. Mass.:
28406.59
Organism:
Homo sapiens (Human)
Description:
P31213
Residue:
254
Sequence:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
  
Inhibitor
Name:
BDBM50369335
Synonyms:
CHEMBL1201841
Type:
Small organic molecule
Emp. Form.:
C22H32N2O2
Mol. Mass.:
356.5017
SMILES:
CC(C)(C)NC(=O)[C@H]1CC[C@H]2C3CCC4=CC(=O)CCN4C3=CC[C@]12C |r,c:23,t:14|
Structure:
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