Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Ligand
BDBM50057297
Substrate
n/a
Meas. Tech.
ChEMBL_202884 (CHEMBL810002)
IC50
2.7±n/a nM
Citation
 Guarna, ABelle, CMachetti, FOcchiato, EGPayne, AHCassiani, CComerci, ADanza, GDe Bellis, ADini, SMarrucci, ASerio, M 19-nor-10-azasteroids: a novel class of inhibitors for human steroid 5alpha-reductases 1 and 2. J Med Chem 40:1112-29 (1997) [PubMed]  Article
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Type:
Enzyme
Mol. Mass.:
28406.59
Organism:
Homo sapiens (Human)
Description:
P31213
Residue:
254
Sequence:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
  
Inhibitor
Name:
BDBM50057297
Synonyms:
(5aS,7aS,8S,10aS,10bS)-8-Hydroxy-7a-methyl-3,4,6,7,7a,8,9,10,10a,10b,11,12-dodecahydro-5aH-indeno[4,5-c]quinolizin-2-one | CHEMBL269632
Type:
Small organic molecule
Emp. Form.:
C17H25NO2
Mol. Mass.:
275.3859
SMILES:
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CCN34)[C@@H]1CC[C@@H]2O |t:8|
Structure:
Search PDB for entries with ligand similarity: