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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Ligand
BDBM50369334
Substrate
n/a
Meas. Tech.
ChEMBL_205215 (CHEMBL816489)
IC50
>100000±n/a nM
Citation
 Guarna, A; Belle, C; Machetti, F; Occhiato, EG; Payne, AH; Cassiani, C; Comerci, A; Danza, G; De Bellis, A; Dini, S; Marrucci, A; Serio, M 19-nor-10-azasteroids: a novel class of inhibitors for human steroid 5alpha-reductases 1 and 2. J Med Chem 40:1112-29 (1997) [PubMed]  Article
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:
Enzyme
Mol. Mass.:
29472.80
Organism:
Homo sapiens (Human)
Description:
P18405
Residue:
259
Sequence:
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
  
Inhibitor
Name:
BDBM50369334
Synonyms:
CHEMBL1237307
Type:
Small organic molecule
Emp. Form.:
C17H21NO2
Mol. Mass.:
271.3541
SMILES:
C[C@]12CCC3=C4C(=O)CCN=C4CCC3[C@@H]1CCC2=O |r,c:4,10|
Structure:
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