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Target
Coagulation factor X
Ligand
BDBM50080503
Substrate
n/a
Meas. Tech.
ChEMBL_49301 (CHEMBL661582)
Ki
21±n/a nM
Citation
 Ewing, WR; Becker, MR; Manetta, VE; Davis, RS; Pauls, HW; Mason, H; Choi-Sledeski, YM; Green, D; Cha, D; Spada, AP; Cheney, DL; Mason, JS; Maignan, S; Guilloteau, JP; Brown, K; Colussi, D; Bentley, R; Bostwick, J; Kasiewski, CJ; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Design and structure-activity relationships of potent and selective inhibitors of blood coagulation factor Xa. J Med Chem 42:3557-71 (1999) [PubMed]  Article
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50080503
Synonyms:
3-{(S)-3-[(7-Methoxy-naphthalene-2-sulfonyl)-(1H-pyrazol-3-ylmethyl)-amino]-2-oxo-pyrrolidin-1-ylmethyl}-benzamidine | CHEMBL119964
Type:
Small organic molecule
Emp. Form.:
C27H28N6O4S
Mol. Mass.:
532.614
SMILES:
COc1ccc2ccc(cc2c1)S(=O)(=O)N(Cc1ccn[nH]1)[C@H]1CCN(Cc2cccc(c2)C(N)=N)C1=O
Structure:
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