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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50081370
Substrate
n/a
Meas. Tech.
ChEMBL_201434 (CHEMBL809837)
IC50
29±n/a nM
Citation
 Nakazato, A; Kumagai, T; Ohta, K; Chaki, S; Okuyama, S; Tomisawa, K Synthesis and SAR of 1-alkyl-2-phenylethylamine derivatives designed from N,N-dipropyl-4-methoxy-3-(2-phenylethoxy)phenylethylamine to discover sigma(1) ligands. J Med Chem 42:3965-70 (1999) [PubMed]
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50081370
Synonyms:
CHEMBL340587 | [1-(4-Methoxy-3-phenethyloxy-benzyl)-pentyl]-dipropyl-amine
Type:
Small organic molecule
Emp. Form.:
C27H41NO2
Mol. Mass.:
411.6199
SMILES:
CCCCC(Cc1ccc(OC)c(OCCc2ccccc2)c1)N(CCC)CCC
Structure:
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