Reaction Details  Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50084316
Substrate
n/a
Meas. Tech.
ChEMBL_201885 (CHEMBL809040)
IC50
860±n/a nM
Citation
 Oshiro, Y; Sakurai, Y; Sato, S; Kurahashi, N; Tanaka, T; Kikuchi, T; Tottori, K; Uwahodo, Y; Miwa, T; Nishi, T 3,4-dihydro-2(1H)-quinolinone as a novel antidepressant drug: synthesis and pharmacology of 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-3,4- dihydro-5-methoxy-2(1H)-quinolinone and its derivatives. J Med Chem 43:177-89 (2000) [PubMed]
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50084316
Synonyms:
1-(4-Fluoro-phenyl)-4-(5-fluoro-pyridin-2-yl)-4-piperazin-1-yl-butan-1-ol | CHEMBL54691
Type:
Small organic molecule
Emp. Form.:
C19H23F2N3O
Mol. Mass.:
347.4022
SMILES:
OC(CCC(N1CCNCC1)c1ccc(F)cn1)c1ccc(F)cc1
Structure:
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