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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50084331
Substrate
n/a
Meas. Tech.
ChEMBL_201885 (CHEMBL809040)
IC50
2470±n/a nM
Citation
 Oshiro, Y; Sakurai, Y; Sato, S; Kurahashi, N; Tanaka, T; Kikuchi, T; Tottori, K; Uwahodo, Y; Miwa, T; Nishi, T 3,4-dihydro-2(1H)-quinolinone as a novel antidepressant drug: synthesis and pharmacology of 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-3,4- dihydro-5-methoxy-2(1H)-quinolinone and its derivatives. J Med Chem 43:177-89 (2000) [PubMed]
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50084331
Synonyms:
3-{4-[3-(5-Methoxy-2-oxo-3,4-dihydro-2H-quinolin-1-yl)-propyl]-piperazin-1-yl}-benzonitrile (HCl.1/2H2O) | CHEMBL59210
Type:
Small organic molecule
Emp. Form.:
C24H28N4O2
Mol. Mass.:
404.5047
SMILES:
COc1cccc2N(CCCN3CCN(CC3)c3cccc(c3)C#N)C(=O)CCc12
Structure:
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