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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Ligand
BDBM50072192
Substrate
n/a
Meas. Tech.
ChEMBL_205064 (CHEMBL810258)
IC50
5130±n/a nM
Citation
 Guarna, A; Machetti, F; Occhiato, EG; Scarpi, D; Comerci, A; Danza, G; Mancina, R; Serio, M; Hardy, K Benzo[c]quinolizin-3-ones: a novel class of potent and selective nonsteroidal inhibitors of human steroid 5alpha-reductase 1. J Med Chem 43:3718-35 (2000) [PubMed]
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:
Enzyme
Mol. Mass.:
29472.80
Organism:
Homo sapiens (Human)
Description:
P18405
Residue:
259
Sequence:
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
  
Inhibitor
Name:
BDBM50072192
Synonyms:
3,4,5,6-Tetrahydrobenzo[c]quinolizin-3-(4aH)-one | 4,4a,5,6-Tetrahydro-pyrido[1,2-a]quinolin-3-one | CHEMBL99448
Type:
Small organic molecule
Emp. Form.:
C13H13NO
Mol. Mass.:
199.2484
SMILES:
O=C1CC2CCc3ccccc3N2C=C1 |c:15|
Structure:
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