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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Ligand
BDBM50092503
Substrate
n/a
Meas. Tech.
ChEMBL_205063 (CHEMBL810257)
IC50
15.8±n/a nM
Citation
 Guarna, A; Machetti, F; Occhiato, EG; Scarpi, D; Comerci, A; Danza, G; Mancina, R; Serio, M; Hardy, K Benzo[c]quinolizin-3-ones: a novel class of potent and selective nonsteroidal inhibitors of human steroid 5alpha-reductase 1. J Med Chem 43:3718-35 (2000) [PubMed]
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:
Enzyme
Mol. Mass.:
29472.80
Organism:
Homo sapiens (Human)
Description:
P18405
Residue:
259
Sequence:
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
  
Inhibitor
Name:
BDBM50092503
Synonyms:
4,6-dimethyl-8-methyl-1,2,5,6-tetrahydro pyrido[1,2-a]quinolin-3-one | CHEMBL125257
Type:
Small organic molecule
Emp. Form.:
C16H19NO
Mol. Mass.:
241.3282
SMILES:
CC1CC2=C(C)C(=O)CCN2c2ccc(C)cc12 |c:3|
Structure:
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