Reaction Details  Report a problem with these data
Target
D(4) dopamine receptor
Ligand
BDBM50094497
Substrate
n/a
Meas. Tech.
ChEMBL_61185 (CHEMBL670999)
Ki
110±n/a nM
Citation
 Hübner, H; Kraxner, J; Gmeiner, P Cyanoindole derivatives as highly selective dopamine D(4) receptor partial agonists: solid-phase synthesis, binding assays, and functional experiments. J Med Chem 43:4563-9 (2000) [PubMed]
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50094497
Synonyms:
3-[4-(4-Fluoro-phenyl)-piperazin-1-ylmethyl]-1H-indole-5-carbonitrile | CHEMBL140165
Type:
Small organic molecule
Emp. Form.:
C20H19FN4
Mol. Mass.:
334.3901
SMILES:
Fc1ccc(cc1)N1CCN(Cc2c[nH]c3ccc(cc23)C#N)CC1
Structure:
Search PDB for entries with ligand similarity: