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Target
D(2) dopamine receptor
Ligand
BDBM50094502
Substrate
n/a
Meas. Tech.
ChEMBL_61813 (CHEMBL672577)
Ki
480±n/a nM
Citation
 Hübner, H; Kraxner, J; Gmeiner, P Cyanoindole derivatives as highly selective dopamine D(4) receptor partial agonists: solid-phase synthesis, binding assays, and functional experiments. J Med Chem 43:4563-9 (2000) [PubMed]
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50094502
Synonyms:
3-[4-(3,4-Dichloro-phenyl)-piperazin-1-ylmethyl]-1H-indole-5-carbonitrile | CHEMBL344270
Type:
Small organic molecule
Emp. Form.:
C20H18Cl2N4
Mol. Mass.:
385.29
SMILES:
Clc1ccc(cc1Cl)N1CCN(Cc2c[nH]c3ccc(cc23)C#N)CC1
Structure:
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