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Target
72 kDa type IV collagenase
Ligand
BDBM50084289
Substrate
n/a
Meas. Tech.
ChEMBL_104369 (CHEMBL715830)
IC50
6.6±n/a nM
Citation
 Pikul, S; Ohler, NE; Ciszewski, G; Laufersweiler, MC; Almstead, NG; De, B; Natchus, MG; Hsieh, LC; Janusz, MJ; Peng, SX; Branch, TM; King, SL; Taiwo, YO; Mieling, GE Potent and selective carboxylic acid-based inhibitors of matrix metalloproteinases. J Med Chem 44:2499-502 (2001) [PubMed]
Target
Name:
72 kDa type IV collagenase
Synonyms:
72 kDa gelatinase | 72 kDa type IV collagenase precursor | CLG4A | Gelatinase A | Gelatinase A (MMP-2) | MMP2 | MMP2_HUMAN | Matrix metalloproteinase-2 | Matrix metalloproteinase-2 (MMP 2) | Matrix metalloproteinase-2 (MMP2) | Matrix metalloproteinases 2 (MMP-2) | TBE-1
Type:
Enzyme
Mol. Mass.:
73870.36
Organism:
Homo sapiens (Human)
Description:
P08253
Residue:
660
Sequence:
MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
  
Inhibitor
Name:
BDBM50084289
Synonyms:
(S)-2-(4'-methoxy-biphenyl-4-sulfonylamino)-3-methyl-butyric acid | 2-(4'-Methoxy-biphenyl-4-sulfonylamino)-3-methyl-butyric acid | CHEMBL44383
Type:
Small organic molecule
Emp. Form.:
C18H21NO5S
Mol. Mass.:
363.428
SMILES:
COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)C(O)=O
Structure:
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