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Target
Interstitial collagenase
Ligand
BDBM50102477
Substrate
n/a
Meas. Tech.
ChEMBL_105963 (CHEMBL878467)
IC50
8.1±n/a nM
Citation
 Pikul, S; Ohler, NE; Ciszewski, G; Laufersweiler, MC; Almstead, NG; De, B; Natchus, MG; Hsieh, LC; Janusz, MJ; Peng, SX; Branch, TM; King, SL; Taiwo, YO; Mieling, GE Potent and selective carboxylic acid-based inhibitors of matrix metalloproteinases. J Med Chem 44:2499-502 (2001) [PubMed]
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
  
Inhibitor
Name:
BDBM50102477
Synonyms:
4-[Carboxy-(4'-methoxy-biphenyl-4-sulfonylamino)-methyl]-piperidine-1-carboxylic acid 2-methoxy-ethyl ester | CHEMBL311266
Type:
Small organic molecule
Emp. Form.:
C24H30N2O8S
Mol. Mass.:
506.569
SMILES:
COCCOC(=O)N1CCC(CC1)C(NS(=O)(=O)c1ccc(cc1)-c1ccc(OC)cc1)C(O)=O
Structure:
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