Reaction Details  Report a problem with these data
Target
Adenosine deaminase
Ligand
BDBM50105934
Substrate
n/a
Meas. Tech.
ChEMBL_30812 (CHEMBL645087)
Ki
8300±n/a nM
Citation
 Hakimelahi, GH; Ly, TW; Moosavi-Movahedi, AA; Jain, ML; Zakerinia, M; Davari, H; Mei, HC; Sambaiah, T; Moshfegh, AA; Hakimelahi, S Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses. J Med Chem 44:3710-20 (2001) [PubMed]
Target
Name:
Adenosine deaminase
Synonyms:
ADA | ADA_BOVIN | Adenosine aminohydrolase
Type:
Enzyme
Mol. Mass.:
40910.44
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
363
Sequence:
MAQTPAFNKPKVELHVHLDGAIKPETILYYGRKRGIALPADTPEELQNIIGMDKPLSLPEFLAKFDYYMPAIAGCREAVKRIAYEFVEMKAKDGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVSLVNQGLQEGERDFGVKVRSILCCMRHQPSWSSEVVELCKKYREQTVVAIDLAGDETIEGSSLFPGHVKAYAEAVKSGVHRTVHAGEVGSANVVKEAVDTLKTERLGHGYHTLEDATLYNRLRQENMHFEVCPWSSYLTGAWKPDTEHPVVRFKNDQVNYSLNTDDPLIFKSTLDTDYQMTKNEMGFTEEEFKRLNINAAKSSFLPEDEKKELLDLLYKAYGMPSPASAEQCL
  
Inhibitor
Name:
BDBM50105934
Synonyms:
2-(6-Amino-purin-7-ylmethoxy)-ethanol | CHEMBL126093
Type:
Small organic molecule
Emp. Form.:
C8H11N5O2
Mol. Mass.:
209.2052
SMILES:
Nc1ncnc2ncn(COCCO)c12
Structure:
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