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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50112421
Substrate
n/a
Meas. Tech.
ChEMBL_221654 (CHEMBL823231)
IC50
290±n/a nM
Citation
 Lange, G; Lesuisse, D; Deprez, P; Schoot, B; Loenze, P; Bénard, D; Marquette, JP; Broto, P; Sarubbi, E; Mandine, E Principles governing the binding of a class of non-peptidic inhibitors to the SH2 domain of src studied by X-ray analysis. J Med Chem 45:2915-22 (2002) [PubMed]
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50112421
Synonyms:
CHEMBL286258 | Phosphoric acid mono-(4-{2-acetylamino-2-[2-oxo-1-(3-phenyl-propyl)-azepan-3-ylcarbamoyl]-ethyl}-phenyl) ester
Type:
Small organic molecule
Emp. Form.:
C26H34N3O7P
Mol. Mass.:
531.5378
SMILES:
CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@H]1CCCCN(CCCc2ccccc2)C1=O
Structure:
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