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Target
Sodium/hydrogen exchanger 1
Ligand
BDBM50115239
Substrate
n/a
Meas. Tech.
ChEMBL_141044 (CHEMBL746892)
IC50
17±n/a nM
Citation
 Fukumoto, S; Imamiya, E; Kusumoto, K; Fujiwara, S; Watanabe, T; Shiraishi, M Novel, non-acylguanidine-type Na(+)/H(+) exchanger inhibitors: synthesis and pharmacology of 5-tetrahydroquinolinylidene aminoguanidine derivatives. J Med Chem 45:3009-21 (2002) [PubMed]
Target
Name:
Sodium/hydrogen exchanger 1
Synonyms:
NHE-1 | Na(+)/H(+) exchanger 1 | Nhe1 | SL9A1_RAT | Slc9a1 | Solute carrier family 9 member 1
Type:
PROTEIN
Mol. Mass.:
91655.00
Organism:
Rattus norvegicus
Description:
ChEMBL_862370
Residue:
820
Sequence:
MMLRWSGIWGLYPPRIFPSLLVVVALVGLLPVLRSHGLQLNPTASTIRGSEPPRERSIGDVTTAPSEPLHHPDDRNLTNLYIEHGAKPVRKAFPVLDIDYLHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLLYAVCLVGGEQINNIGLLDTLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFASYEYVGISDIFLGFLSFFVVSLGGVFVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHQWNWTFVISTLLFCLIARVLGVLVLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSAASERILPALSKDKEEEIRKILRSNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKITNYLTVPAHKLDSPTMSRARIGSDPLAYEPKADLPVITIDPASPQSPESVDLVNEELKGKVLGLKRGPRTTPEEEEEDEDGVIMIRSKEPSSPGTDDVFTPGPSDSPGSQRIQRCLSDPGPHPEPGEGEPFIPKGQ
  
Inhibitor
Name:
BDBM50115239
Synonyms:
(S)-N-[7-(2,5-dichloro-3-thienyl)-4-methyl-(7S)-5,6,7,8-tetrahydro-5-quinolinyliden(imine)]iminomethanediamine 2CH3SO3H | CHEMBL316541
Type:
Small organic molecule
Emp. Form.:
C15H15Cl2N5S
Mol. Mass.:
368.284
SMILES:
[#6]-c1ccnc2-[#6]-[#6@H](-[#6]-[#6](=[#7]\[#7]=[#6](\[#7])-[#7])-c12)-c1cc(Cl)sc1Cl |w:10.10|
Structure:
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